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INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

National Institutes of Health

posted

Award ceiling

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Award floor

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Posted

May 12, 2026

Closes

Jun 15, 2028

Location eligibility

No specific state restriction found in this listing — check the full opportunity for details.

Categories: Health

Eligible applicants: County governments, Native American tribal governments (Federally recognized), City or township governments, Private institutions of higher education, Independent school districts, Others (see text field entitled "Additional Information on Eligibility" for clarification), For profit organizations other than small businesses, Native American tribal organizations (other than Federally recognized tribal governments), Special district governments, State governments, Public and State controlled institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Public housing authorities/Indian housing authorities, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

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