Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
National Institutes of Health
Award ceiling
—Award floor
—Posted
Sep 22, 2025Closes
Jul 20, 2028Location eligibility
No specific state restriction found in this listing — check the full opportunity for details.Categories: Health, Income Security and Social Services
Eligible applicants: Private institutions of higher education, City or township governments, Small businesses, Special district governments, Independent school districts, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Public housing authorities/Indian housing authorities, For profit organizations other than small businesses, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, County governments, Public and State controlled institutions of higher education, State governments, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments)
Description
This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling efficient and effective movement of candidate therapeutics or diagnostics toward clinical trials, and to increase their likelihood of success. This could be through the development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.