Metastasis Research Network (U54 Clinical Trial Not Allowed)
National Institutes of Health
Award ceiling
—Award floor
—Posted
Jun 4, 2026Closes
Sep 25, 2026Location eligibility
No specific state restriction found in this listing — check the full opportunity for details.Categories: Health
Eligible applicants: Independent school districts, Native American tribal governments (Federally recognized), Special district governments, Small businesses, Native American tribal organizations (other than Federally recognized tribal governments), Public and State controlled institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Public housing authorities/Indian housing authorities, City or township governments, For profit organizations other than small businesses, State governments, Private institutions of higher education, County governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.